HIV-1 gp41 (Group O Variant)

Recombinant HIV-1 gp41 (Group O Variant) is a high-purity envelope glycoprotein developed to expand diagnostic coverage across genetically diverse HIV-1 variants. As the transmembrane component of the HIV envelope complex, gp41 mediates membrane fusion during viral entry and elicits a strong antibody response early in infection, making it a key antigen for HIV serological assays. The inclusion of a Group O-specific gp41 antigen enhances the detection of antibodies against this genetically divergent HIV-1 lineage, which is predominantly found in West and Central Africa but has also been identified globally through travel and migration. Recombinant gp41 (Group O Variant) is an important reagent for developing broadly inclusive HIV immunoassays with improved global diagnostic coverage.